Pearl River is a hamlet and census-designated place in the town of Orangetown, Rockland County, New York, United States. It is located east of Chestnut Ridge, south of Nanuet, west of Blauvelt, New York, and north of Montvale and Old Tappan, New Jersey. The population was 15,876 at the 2010 census.
Pearl River is 20 miles (32 km) north of midtown Manhattan and lies just north of the New Jersey border. It is the first (traveling north) of three New York stops on New Jersey Transit's Pascack Valley Line.
Pearl River is the site of One Blue Hill Plaza, Rockland County's first commercial skyscraper, with 21 stories of office space.
In 1906, Ernest Lederle, the former commissioner of the New York City Department of Health and Mental Hygiene, founded Lederle Laboratories (which became Wyeth and is now Pfizer) on a farm which now encompasses 550 acres (2.2 km2), 40 buildings, and until recently employed around 3,200 workers. The number of employees here has dwindled to the hundreds since the Pfizer takeover.
In 2011, CNNMoney.com ranked Pearl River 78th on its annual "100 Best Places to Live" list.(Wikipedia)